112年第1學期-5370 結構生物化學 課程資訊

評分方式

評分項目	配分比例	說明
小考 期中考 期末考	50	視成績而略有改變比例

教育目標

1. Structure and ionization properties of amino acids and polypeptides. Ionization equations and calculation of the net charge of polypeptides. 2. Secondary structures of proteins, the Ramachandran angles(dihedral angles) of peptides. Modern concepts of molecular recognitions, receptors, receptor-ligand interactions, enzyme-substrate interactions. The Scatchard equation. 3. Enzyme kinetics, derivation and applications of the Michaelis-Menten equation. 4. Importance of enzyme inhibitors and applications in modern drug developments. Derivation of the equations for competitive enzyme inhibitors. Enzyme catalytic principles and mechanisms: Serine proteases, Aconitase, Carboxypeptidase. Coenzyme and mechanisms 5. DNA structure, major groove and minor groove figures. DNA-protein interactions, DNA-small ligand interactions. Restriction endonuclease mechanisms.

基本資料

選修課，學分數：2-0
上課時間：四/3,4[CH012]
修課班級：化學系4,碩博1,2
修課年級：1年級以上
選課備註：大四可選

參考書目

Reading major journals such as Nature, Science, PNAS, J.Am.Chem.Soc., J.Biol.Chem.