99年第2學期-4323 免疫逃避機制 課程資訊

評分方式

評分項目	配分比例	說明
口頭報告	50
參與討論	50

教育目標

本課程的目的在於探討病原 (pathogens，如細菌、病毒、黴菌、寄生蟲等) 為何能逃避宿主免疫反應的攻擊而得以存活。同時也將探討在特定的生理需要下，為何身體能不產生免疫反應？例如身體不會排斥攝取的食物、腸內益生菌或胎兒。本課程將利用文獻的原始資料來討論抗原與宿主反應之間的相互關係，進而瞭解免疫系統的功能及機制。

基本資料

選修課，學分數：0-2
上課時間：一/3,4[BS401]
修課班級：生科碩博1
修課年級：年級以上
選課備註：大四可選；先修免疫學；第一堂課出席者方可選修

參考書目

Reviews:

1. Anti-immunology: evasion of the host immune system by bacterial and viral pathogens. Cell 124:
767-782, 2006.

2. Immune evasion by staphylococci. Nat Rev Microbiol 3:948-958, 2005.



Original papers:

1. Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human
cytomegalovirus during the latent phase of infection. J Virol 82: 3736, 2008.

2. Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus
expression and restoration of signaling by IKK. J Virol 79:3969, 2005.

3. Cholesterol glucosylation promotes immune evasion by Helicobacter pylori. Nat Med 12: 1030,
2006.

4. A Chemokine-Degrading Extracellular Protease Made by Group A Streptococcus Alters Pathogenesis
by Enhancing Evasion of the Innate immune response. Infect Immun 76: 978, 2008.

5. Host shutoff during productive Epstein–Barr virus infection is mediated by BGLF5 and may
contribute to immune evasion. PNAS 104: 3366, 2007.

6. Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response. Nat
Immunol 7: 1066, 2006.

7. Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the
NKG2D ligands major histocompatibility complex class I chain-related proteins A and B. J Virol
82: 4585, 2008.

8. Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases. Nat
Immunol 6: 920, 2005.

9. The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human
epithelial cells and promotes host-microbe homeostasis. Inf Immun76: 4163, 2008.