110年第1學期-5372 蛋白質折疊與疾病 課程資訊

評分方式

評分項目	配分比例	說明
課堂 paper 閱讀準備	50
期末考試	20
期中考試	20
出席	10

教育目標

This course aims to broaden the knowledge of protein folding/misfolding and to relate it to the human diseases.

基本資料

選修課，學分數：1-0
上課時間：四/7[CH012]
修課班級：化學系4,碩博1,2
修課年級：年級以上
選課備註：大四可選

參考書目

1. Ken A. Dill and Justin L. MacCallum, The Protein-Folding Problem, 50 Years On. Science, 2012, p1042-1046.
2. F. Ulrich Hartl, Molecular Chaperons in Cellular Protein Folding, Nature, 1996, v.381, p571-580.
3. “The importance of protein folding” by Joachim Pietzsch
4. F. Ulrich Hartl, Protein Misfolding Diseases, Annu. Rev. Biochem. 2017, V.86, p21–26.
5. Fabrizio Chiti and Christopher M. Dobson, Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade, Annu. Rev. Biochem. 2017, V.86, p27–68.
6. Surabhi Mehra, Shruti Sahay and Samir K. Maji, BBA - Proteins and Proteomics,
https://doi.org/10.1016/j.bbapap.2019.03.001
7. Whitechurch B.C., Welton J.M., Collins S.J., Lawson V.A. (2017) Prion Diseases. In: Beart P., Robinson M., Rattray M., Maragakis N. (eds) Neurodegenerative Diseases. Advances in Neurobiology, vol 15. Springer, Cham
8. “ Treating protein folding diseases” by Sophie Petit-Zeman