1. Structure and ionization properties of amino acids and polypeptides. Ionization equations and calculation of the net charge of polypeptides. 2. Secondary structures of proteins, the Ramachandran angles(dihedral angles) of peptides. Modern concepts of molecular recognitions, receptors, receptor-ligand interactions, enzyme-substrate interactions. The Scatchard equation. 3. Enzyme kinetics, derivation and applications of the Michaelis-Menten equation. 4. Importance of enzyme inhibitors and applications in modern drug developments. Derivation of the equations for competitive enzyme inhibitors. Enzyme catalytic principles and mechanisms: Serine proteases, Aconitase, Carboxypeptidase. Coenzyme and mechanisms 5. DNA structure, major groove and minor groove figures. DNA-protein interactions, DNA-small ligand interactions. Restriction endonuclease mechanisms.

Reading major journals such as Nature, Science, PNAS, J.Am.Chem.Soc., J.Biol.Chem.