課程主軸為化學平衡，以氣體的性質為起點，接續熱力學各大定律、純物質與混合物的性質、相圖及化學平衡，提供化學平衡所需要的概念。

講授化學平衡，分子運動，擴散問題，反應動力學，固體表面過程，統計熱力學。

教科書：
Physical Chemistry: Quanta, Matter, and Change, 2nd Ed. Peter Atkins, Julio de Paula, and Ronald Friedman
參考書:
Atkins' Physical Chemistry (by Peter Atkins, Julio de Paula, and James Keeler)
Physical Chemistry (by Thomas Engel and Philip Reid)
Physical Chemistry (by Levine)
Students Solutions Manual to Accompany Physical Chemistry: Quanta, Matter, and Change