108年第1學期-5372 結構生物化學 課程資訊

評分方式

評分項目	配分比例	說明
期中考, 期末考	50	有小考
期末考	50

教育目標

This course will begin by introducing the fundamental biochemical concepts such as the stereochemical aspects of amino acids, peptides, proteins and nucleic acids, receptor-ligand interactions, enzyme-substrate interactions. More advanced topics such as complex enzyme and coenzyme mechanisms, specific molecular interactions of protein-ligand and DNA-small ligand will be taught. 2.0 credits are suggested for this course. 課程大綱 1. Structure and ionization properties of amino acids and polypeptides. Ionization equations and calculation of the net charge of polypeptides. 2. Secondary structures of proteins, the Ramachandran angles(dihedral angles) of peptides. Concepts of receptors, receptors ligand interactions, enzyme-substrate interactions. The Scatchard equation. 3. Importance of enzyme inhibitors and applications in modern drug developments. Derivation of the equations for competitive enzyme inhibitors 4. Enzyme catalytic principles and mechanisms: Aconitase, Carboxypeptidase, DNase I, Ribonuclease. Coenzyme and mechanisms: NADH (with X-ray structure of the enzyme-coenzyme complex), Biotin, Vitamin B12 5. DNA structure, major groove and minor groove figures. DNA-protein interactions, DNA-small ligand interactions. Restriction endonuclease mechanisms.

基本資料

選修課，學分數：2-0
上課時間：二/3,4[CH012]
修課班級：化學系4,碩博1,2
修課年級：年級以上
選課備註：大四可選

參考書目

Biochemistry by Garrett and Grisham
References from major journals